Bioprocess Engineering

Semester Taught - Fall

Catalog Description

Credits: 3

The course will cover engineering principles, processes and techniques for using biological agents such as cells, enzymes or antibodies for the production of chemicals, food, biofuels and pharmaceuticals, and waste treatment.  The course will include stoichiometry and kinetics of reactions that employ biological agents; design, analysis and operation of reactors (fermentors); and product recovery and purification (downstream processing).


Life Sciences, Biological, Chemical or Environmental Engineering coursework

Course Objectives

The objectives of the course are to develop concepts and mathematical tools required to understand and analyze,

  • processes involved in production of chemicals, food, biofuels and pharmaceuticals using biological agents.
  • design and operation of reactors using biological agents
  • unit operations and processes for product recovery
  • economics of bioprocesses


Pratap Pullammanappillil
Office - 203 Frazier Rogers Hall
Telephone (352) 392-1864 x203
E-mail address: pcpratap@ufl.edu

Material/Supply Fees


Class Materials Required

Textbook required:

Title: Bioprocess Engineering Principles
Author: Pauline M. Doran
Publisher: Academic Press, 2007 (11th reprint)
ISBN-13: 978-0-12-220856-0

Recommended Reading:

  1. Bioprocess Engineering – Basic Concepts, Shuler and Kargi, Second Edition 2002, Prentice Hall
  2. Principles of Fermentation Technology by Stanbury, Whitaker and Hall, Second Edition 2003, Butterworth Heinemann.
  3. Biochemical Engineering, Bailey and Ollis, 1986, McGraw Hill

Course Outline

  • Material and Energy Balances
  • Stoichiometry and energetics of microbial growth and product formation
  • Principles of Enzyme Catalysis
  • Cell Growth
  • Heterogeneous Reactions
  • Operating Considerations for bioreactors
  • Bioreactor Design and Analysis
  • Analysis of mixed cultures
  • Downstream processing
  • Bioprocess Economics


Grades will be based upon field trip reports, homework problems, and class participation.

A 91-100
A- 86-90
B+ 81-85
B 76-80
B- 71-75
C+ 66-70
C 61-65
C- 56-60
D+ 51-55
D 46-50
D- 40-45
E <40
Grading MethodPercentage
Homework 50%
Exam 20%
Project 30%

Attendance and Expectations: Attendance at all lectures is expected from all students at all times. Homework is due within one week of when assigned.

Make-up Exam Policy:  No make-up exams will be given except for valid medical reasons or unless prior arrangements have been made.

Academic Honesty

All students admitted to the University of Florida have signed a statement of academic honesty committing themselves to be honest in all academic work and understanding that failure to comply with this commitment will result in disciplinary action. This statement is a reminder to uphold your obligation as a UF student and to be honest in all work submitted and exams taken in this course and all others.

Accommodation for Students with Disabilities

Students requesting classroom accommodation must first register with the Dean of Students Office. That office will provide the student with documentation that he/she must provide to the course instructor when requesting accommodation.

Use of Library, Personal References, PC Programs and Electronic Databases

These items are university property and should be utilized with other users in mind. Never remove, mark, modify nor deface resources that do not belong to you. If you're in the habit of underlining text, do it only on your personal copy. It is inconsiderate, costly to others, and dishonest to use common references otherwise.

Software Use

All faculty, staff and students of the University are required and expected to obey the laws and legal agreements governing software use. Failure to do so can lead to monetary damages and/or criminal penalties for the individual violator. Because such violations are also against University policies and rules, disciplinary action will be taken as appropriate. We, the members of the University of Florida community, pledge to hold ourselves and our peers to the highest standards of honesty and integrity.

UF Counseling and Career Services

Resources are available on-campus for students having personal problems or lacking clear career and academic goals which interfere with their academic performance. These resources include:

  1. University Counseling and Wellness Center, 3190 Radio Road, Gainesville, FL 32611
  2. Career Connections Center, Reitz Union, 392-1601, career development assistance and counseling.